Evidence map›Paper›PMID 41676647›Full record

ArticlebioRxiv : the preprint server for biology2026

Modeling binding of the conserved Csr/Rsm protein family across species of the γ-proteobacteria reveals niche-specific adaptation of the post-transcriptional regulon.

Alexandra J Lukasiewicz, Lily G Hoefner, Ani Savk, Lydia M Contreras

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alexandra J LukasiewiczDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX, United States.
Lily G HoefnerDepartment of Biology, The University of Texas at Austin, Austin, TX, United States.
Ani SavkMcKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, United States.
Lydia M ContrerasMcKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, United States.

Funding

Novel mechanisms of posttranscriptional regulation by CsrAR01GM135495 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI CONTRERAS, LYDIA MARIA · 2020 to 2024
$1.8M
NIGMS NIH HHS R01 GM135495
6 · The paper itself

Abstract

The γ-proteobacteria are an exceptionally diverse bacterial class whose members thrive in environments from deep-sea vents to human intestinal tracts. Rapid gene expression responses mediated by global post-transcriptional regulatory networks like the Csr/Rsm system are critical for bacterial survival in dynamic niches. CsrA/RsmA functions as a global regulatory RNA-binding protein, directly controlling hundreds to thousands of mRNA targets simultaneously across the transcriptome to coordinate systems-level metabolic and behavioral responses. Despite conservation of the CsrA/RsmA regulatory protein across γ-proteobacteria, the genes it regulates in different species remain poorly characterized. We extended a previously developed biophysical model of CsrA/RsmA-RNA binding from

Indexed as

Computational biologyEcology and evolutionPost-transcriptional regulationRNA-binding proteinsThermodynamic modeling

Identifiers

PMID41676647
PMCPMC12889724

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.