Evidence map›Paper›PMID 41676635›Full record

ArticlebioRxiv : the preprint server for biology2026

Multi-echo BOLD fMRI improves cerebrovascular reactivity estimates in stroke.

Rebecca G Clements, Fatemeh Geranmayeh, Niamh V Parkinson, Miguel Montero, Sebastian Urday, Katie Taran, Diego A Caban-Rivera, Carson Ingo, Molly G Bright

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rebecca G ClementsDepartment of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0002-4787-1124
Fatemeh GeranmayehDepartment of Brain Sciences, Faculty of Medicine, Imperial College London, London, United Kingdom.ORCID 0000-0003-1112-786X
Niamh V ParkinsonDepartment of Brain Sciences, Faculty of Medicine, Imperial College London, London, United Kingdom.ORCID 0009-0006-5106-3556
Miguel MonteroDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Sebastian UrdayDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0009-0008-2747-1503
Katie TaranDepartment of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Diego A Caban-RiveraDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0002-8977-8147
Carson IngoDepartment of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0001-8430-931X
Molly G BrightDepartment of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0001-7257-9646

Funding

Post-stroke normal appearing white matter diffusion properties and cognitive trajectories across ageR01NS126509 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Carson J Ingo · 2023 to 2026
$2.9M
NINDS NIH HHS R01 NS126509
6 · The paper itself

Abstract

Cerebrovascular reactivity (CVR), the ability of cerebral blood vessels to dilate or constrict in response to a vasoactive stimulus, is a clinically meaningful measure of cerebrovascular health. Head motion and other noise sources substantially impact CVR quality, particularly in clinical populations. In this study, we evaluated multi-echo fMRI techniques, including optimal combination of echoes (ME-OC) and multi-echo independent component analysis (ME-ICA), for improving CVR quality relative to single-echo fMRI in participants with stroke. In a breath-hold fMRI dataset, ME-OC significantly improved CVR quality metrics and reduced the percentage of negative CVR values in normal-appearing gray and white matter (

Indexed as

breath-hold fMRIcerebrovascular reactivitymulti-echo fMRIresting-state fMRIstroke

Identifiers

PMID41676635
PMCPMC12889588

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.