Evidence map›Paper›PMID 41676622›Full record

ArticlebioRxiv : the preprint server for biology2026

Supercharging the calcium pump: Identification of an activation hotspot on SERCA by cryo-EM.

Vinh H Nguyen, Carlos Cruz-Cortés, Joseph O Primeau, M Joanne Lemieux, L Michel Espinoza-Fonseca, Howard S Young

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Vinh H NguyenDepartment of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.
Carlos Cruz-CortésCenter for Arrhythmia Research, Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Joseph O PrimeauDepartment of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.
M Joanne LemieuxDepartment of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.ORCID 0000-0003-4745-9153
L Michel Espinoza-FonsecaCenter for Arrhythmia Research, Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Howard S YoungDepartment of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.ORCID 0000-0002-5990-8422

Funding

The Stanford-SLAC CryoEM CenterR24GM154186 · NIGMS · STANFORD UNIVERSITY · PI Wah Chiu, BRITT HEDMAN · 2024 to 2026
$19.3M
Hit-to-lead optimization for heart failure drug discoveryR01HL148068 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ESPINOZA-FONSECA, LENNANE MICHEL, HERRON, TODD JOSEPH · 2019 to 2022
$2.9M
Molecular mechanisms and regulation of the calcium pump in the heartR01GM120142 · NIGMS · UNIVERSITY OF MINNESOTA · PI ESPINOZA-FONSECA, LENNANE MICHEL · 2016 to 2020
$1.7M
NHLBI NIH HHS R01 HL148068NIGMS NIH HHS R01 GM120142NIGMS NIH HHS R24 GM154186
6 · The paper itself

Abstract

The sarco-endoplasmic reticulum Ca

Identifiers

PMID41676622
PMCPMC12889739

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.