Evidence map›Paper›PMID 41676553›Full record

ArticlebioRxiv : the preprint server for biology2026

The orientation of cholesterol's hydroxyl group affects its membrane dynamics and intracellular transport.

Line Lauritsen, Amanda Therese Pauli, Miklas P W Larsen, Peter Reinholdt, Holger A Scheidt, Yuanjian Xu, Douglas F Covey, Laura Depta, Hogan Bryce-Rogers, Luca Laraia and 2 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Line LauritsenDepartment of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark.ORCID 0000-0002-6378-571X
Amanda Therese PauliDepartment of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark.
Miklas P W LarsenDepartment of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark.ORCID 0009-0004-4397-3221
Peter ReinholdtDepartment of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark.ORCID 0000-0003-2406-700X
Holger A ScheidtInstitute for Medical Physics and Biophysics, Leipzig University, Härtelstr. 16-18, D-04107.ORCID 0000-0001-9935-8229
Yuanjian XuDepartment of Developmental Biology, Washington University, St. Louis, MO 63110, USA.
Douglas F CoveyDepartment of Developmental Biology, Washington University, St. Louis, MO 63110, USA.ORCID 0000-0002-9316-8683
Laura DeptaDepartment of Chemistry, Technical University of Denmark, Kemitorvet 207, 2800 Kongens Lyngby, Denmark.ORCID 0000-0002-4076-7316
Hogan Bryce-RogersDepartment of Chemistry, Technical University of Denmark, Kemitorvet 207, 2800 Kongens Lyngby, Denmark.ORCID 0000-0002-3186-9601
Luca LaraiaDepartment of Chemistry, Technical University of Denmark, Kemitorvet 207, 2800 Kongens Lyngby, Denmark.ORCID 0000-0001-6692-3412
Jacob KongstedDepartment of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark.ORCID 0000-0002-7725-2164
Daniel WüstnerDepartment of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark.ORCID 0000-0003-4995-9709

Funding

Neuroactive steroids as novel psychiatric treatments: mechanistic studiesP50MH122379 · NIMH · WASHINGTON UNIVERSITY · PI COVEY, DOUGLAS F · 2021 to 2025
$12.2M
NIMH NIH HHS P50 MH122379
6 · The paper itself

Abstract

The brain, though less than 10% of body mass, contains about 25% of total cholesterol (CHL), emphasizing CHL's key role in neuronal function. Many CHL actions are stereospecific, as shown by differences from its 3

Indexed as

Cholesterol transportepimersfluorescencemicroscopyprobestrafficking

Identifiers

PMID41676553
PMCPMC12889547

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.