Evidence map›Paper›PMID 41676522›Full record

ArticlebioRxiv : the preprint server for biology2026

Core-sheath coupling controls flagellar curvature and motility in

F San Martin, M R Brady, L Fule, L Nouchikian, A Rodriguez, S Mondino, N Larrieux, E A Wunder, A I Ko, M Rey and 6 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

F San MartinInstitut Pasteur de Montevideo, Laboratory of Molecular & Structural Microbiology, Montevideo, Uruguay.
M R BradyDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA.
L FuleInstitut Pasteur, Université Paris Cité, Biology of Spirochetes Unit, Paris, France.
L NouchikianInstitut Pasteur, Université Paris Cité, CNRS UAR 2024, Mass Spectrometry for Biology Unit, Paris, France.
A RodriguezInstitut Pasteur de Montevideo & Instituto de Investigaciones Biologicas Clemente Estable, Analytical Biochemistry and Proteomics Unit, Montevideo, Uruguay.
S MondinoInstitut Pasteur de Montevideo, Laboratory of Molecular & Structural Microbiology, Montevideo, Uruguay.ORCID 0009-0002-8637-2210
N LarrieuxInstitut Pasteur de Montevideo, Laboratory of Molecular & Structural Microbiology, Montevideo, Uruguay.ORCID 0000-0002-8027-9544
E A WunderDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.ORCID 0000-0002-5239-8511
A I KoDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.ORCID 0000-0001-9023-2339
M ReyInstitut Pasteur, Université Paris Cité, CNRS UAR 2024, Mass Spectrometry for Biology Unit, Paris, France.
J Chamot-RookeInstitut Pasteur, Université Paris Cité, CNRS UAR 2024, Mass Spectrometry for Biology Unit, Paris, France.
R DuranInstitut Pasteur de Montevideo & Instituto de Investigaciones Biologicas Clemente Estable, Analytical Biochemistry and Proteomics Unit, Montevideo, Uruguay.
F TrajtenbergInstitut Pasteur de Montevideo, Laboratory of Molecular & Structural Microbiology, Montevideo, Uruguay.ORCID 0000-0003-0427-5549
M PicardeauInstitut Pasteur, Université Paris Cité, Biology of Spirochetes Unit, Paris, France.ORCID 0000-0002-5338-5579
C V SindelarDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA.ORCID 0000-0002-6646-7776
A BuschiazzoInstitut Pasteur de Montevideo, Laboratory of Molecular & Structural Microbiology, Montevideo, Uruguay.ORCID 0000-0002-2509-6526

Funding

Virulence and Adaptation to the Host Environment of Pathogenic LeptospiraP01AI168148 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DAVID A HAAKE · 2023 to 2026
$11.8M
PREDOCTORAL PROGRAM IN BIOPHYSICST32GM008283 · NIGMS · YALE UNIVERSITY · PI XIONG, YONG · 1988 to 2022
$10.5M
Natural History of Urban LeptospirosisR01AI052473 · NIAID · YALE UNIVERSITY · PI KO, ALBERT ICKSANG · 2003 to 2013
$2.8M
Development of a Universal Vaccine Against LeptospirosisR01AI182354 · NIAID · UNIVERSITY OF CONNECTICUT STORRS · PI Elsio Augusto Wunder · 2024 to 2026
$2.3M
Evolutionary multispecies transcriptomics to reveal genes conferring pathogenicity within Leptospira sppR21AI163663 · NIAID · YALE UNIVERSITY · PI TOWNSEND, JEFFREY PETER, WUNDER, ELSIO AUGUSTO · 2021 to 2022
$461k
NIAID NIH HHS P01 AI168148NIAID NIH HHS R01 AI052473NIAID NIH HHS R01 AI182354NIAID NIH HHS R21 AI163663NIGMS NIH HHS T32 GM008283
6 · The paper itself

Abstract

Spirochete pathogens are among the most invasive bacteria known, causing syphilis, Lyme disease, and leptospirosis. Their tissue penetration depends on periplasmic flagellar filaments that, unlike other bacterial flagella, are encased in a spirochete-specific multi-protein sheath and deform the cell body into motile waves. How these filaments achieve the mechanical properties needed for invasive motility has remained unclear. Here we determine complete atomic structures of the

Identifiers

PMID41676522
PMCPMC12889604

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.