Evidence map›Paper›PMID 41676501›Full record

ArticlebioRxiv : the preprint server for biology2026

Cell confinement initiates a delayed but heritable loss of chromosomes.

Steven H Phan, Mai Wang, Kayla R Snare, Jonah Kandell, Jeneille S Deans, Panteleimon Rompolas, Guilherme P F Nader, Dennis E Discher

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Steven H PhanMolecular and Cell Biophysics Lab, University of Pennsylvania, Philadelphia, PA 19104, USA.
Mai WangMolecular and Cell Biophysics Lab, University of Pennsylvania, Philadelphia, PA 19104, USA.
Kayla R SnareDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Jonah KandellMolecular and Cell Biophysics Lab, University of Pennsylvania, Philadelphia, PA 19104, USA.
Jeneille S DeansDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Panteleimon RompolasDepartment of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-9135-7651
Guilherme P F NaderDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0002-1905-1903
Dennis E DischerMolecular and Cell Biophysics Lab, University of Pennsylvania, Philadelphia, PA 19104, USA.

Funding

TRANSGENIC AND CHIMERIC MOUSE COREP30DK050306 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI GARY D. WU · 1997 to 2026
$32.5M
Tumor cell instrinsic DNA damage signaling to the immune responseP01CA265794 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Roger A Greenberg · 2023 to 2026
$8.5M
Stiff, solid microenvironments induce Chromosome loss and challenge Epigenetic therapiesU01CA254886 · NCI · UNIVERSITY OF PENNSYLVANIA · PI DISCHER, DENNIS E. · 2021 to 2025
$4.3M
NCI NIH HHS P01 CA265794NCI NIH HHS U01 CA254886NIDDK NIH HHS P30 DK050306
6 · The paper itself

Abstract

Heritable genetic changes continually arise in cancer, especially in solid tumors where cells sometimes appear compressed. Rare heritable losses of chromosomes in live cells are quantified here with chromosome reporters (ChReporters) that reveal similar levels of loss after imposing a threshold level of confinement. Compression to ~60% of interphase height ruptures few nuclei compared to deeper compression but perturbs mitotic spindles and prolongs pro/metaphase. Chromosome mis-segregation into micronuclei is discovered only

Indexed as

AneuploidyCancerCompressionEvolutionGeneticsMechanobiology

Identifiers

PMID41676501
PMCPMC12889681

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.