Evidence map›Paper›PMID 41676498›Full record

ArticlebioRxiv : the preprint server for biology2026

A Large Animal Model of Heritable Pulmonary Arterial Hypertension Using Gene-edited

Sanjeev A Datar, Nicholas Werry, Austin R Brown, Devon S Fitzpatrick, Oluwafemi Falade, Josephine F Trott, Rachel Hutchings, Elena K Amin, Jessica M Morgan, Hythem Nawaytou and 9 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Sanjeev A DatarDepartment of Pediatrics, University of California, San Francisco, CA 94143, USA.ORCID 0009-0003-6986-2821
Nicholas WerryDepartment of Animal Science, University of California, Davis, CA 95616, USA.
Austin R BrownDepartment of Animal Science, University of California, Davis, CA 95616, USA.
Devon S FitzpatrickDepartment of Animal Science, University of California, Davis, CA 95616, USA.
Oluwafemi FaladeDepartment of Animal Science, University of California, Davis, CA 95616, USA.
Josephine F TrottDepartment of Animal Science, University of California, Davis, CA 95616, USA.
Rachel HutchingsDepartment of Pediatrics, University of California, San Francisco, CA 94143, USA.
Elena K AminDepartment of Pediatrics, University of California, San Francisco, CA 94143, USA.
Jessica M MorganSchool of Veterinary Medicine, University of California, Davis, CA 95616, USA.
Hythem NawaytouDepartment of Pediatrics, University of California, San Francisco, CA 94143, USA.
Gail H DeutschDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195.
Eric G JohnsonSchool of Veterinary Medicine, University of California, Davis, CA 95616, USA.
Omar A Gonzales VieraSchool of Veterinary Medicine, University of California, Davis, CA 95616, USA.
Thomas F BishopDepartment of Animal Science, University of California, Davis, CA 95616, USA.
Tara UrbanoSchool of Veterinary Medicine, University of California, Davis, CA 95616, USA.
Bret R McNabbSchool of Veterinary Medicine, University of California, Davis, CA 95616, USA.
Eric D AustinSchool of Medicine, Vanderbilt University, Nashville, TN 37235, USA.
Jeffery R FinemanDepartment of Pediatrics, University of California, San Francisco, CA 94143, USA.
Alison L Van EenennaamDepartment of Animal Science, University of California, Davis, CA 95616, USA.

Funding

PERINATAL PULMONARY HYPERTENSION: DEVELOPMENT MEDIATORSR01HL061284 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FINEMAN, JEFFREY R · 1999 to 2016
$8.3M
Altered Lymphatic Function and Development in Congenital Heart DiseaseR01HL133034 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Sanjeev A. Datar · 2016 to 2026
$6.4M
NHLBI NIH HHS R01 HL061284NHLBI NIH HHS R01 HL133034
6 · The paper itself

Abstract

Pulmonary Arterial Hypertension (PAH) is a rare vascular disorder characterized by elevated pressure in pulmonary arteries, eventually leading to right ventricular failure. Approximately 50% of pediatric disease and 20% of adult disease can be linked to a genetic mutation, with nearly 70% of these cases involving mutations in the bone morphogenetic protein receptor type 2 (

Identifiers

PMID41676498
PMCPMC12889587

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.