Evidence map›Paper›PMID 41676479›Full record

ArticlebioRxiv : the preprint server for biology2026

Rapid peripheral reprogramming of myelinated afferents drives human hyperalgesia.

O Bouchatta, A Marshall, S H Lindström, J Kupari, H Manouze, A Barakat, H Yu, I Szczot, J Johansson, R Saager and 7 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

O BouchattaDepartment of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
A MarshallDepartment of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
S H LindströmDepartment of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
J KupariDepartment of Medical Biochemistry and Biophysics, Division of Molecular Neurobiology, Karolinska Institute, Stockholm, Sweden.
H ManouzeDepartment of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
A BarakatDepartment of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
H YuDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.
I SzczotDepartment of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
J JohanssonDepartment of Biomedical Engineering, Linköping University, Linköping, Sweden.
R SaagerDepartment of Biomedical Engineering, Linköping University, Linköping, Sweden.
M LarssonDepartment of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
W LuoDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.ORCID 0000-0002-2486-807X
A G MarshallDepartment of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
P ErnforsDepartment of Medical Biochemistry and Biophysics, Division of Molecular Neurobiology, Karolinska Institute, Stockholm, Sweden.
H OlaussonDepartment of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
S S NagiDepartment of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.ORCID 0000-0001-8773-8232
NIH PRECISION Human Pain Network

Funding

The Penn Human Precision Pain Center (HPPC): Discovery and Functional Evaluation of Human Primary Somatosensory Neuron Types at Normal and Chronic Pain ConditionsU19NS135528 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Mingyao Li, Wenqin Luo · 2023 to 2026
$11.2M
NINDS NIH HHS U19 NS135528
6 · The paper itself

Abstract

A small burn can render a large area of skin painfully tender. This widespread hyperalgesia protects injured tissue and is typically attributed to altered spinal cord mechanisms. Whether peripheral sensory afferents directly interact to contribute to hyperalgesia remains unclear. Using single-unit microneurography, we recorded cutaneous afferents before and after inducing localized TRPV1-mediated inflammatory flare. This triggered minutes-scale reweighting of transcriptomically defined TRPV1

Identifiers

PMID41676479
PMCPMC12889640

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.