Evidence map›Paper›PMID 41676472›Full record

ArticlebioRxiv : the preprint server for biology2026

Evolution of the rate, molecular spectrum, and fitness effects of mutation under minimal selection in

Sayran Saber, Md Monjurul Islam Rifat, Fahimeh Rahimi, Michael Snyder, Amber Singh, Benjamin Eickwort, Yell Newhall, Moein Rajaei, Ayush Shekhar Saxena, Robyn E Tanny and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Sayran SaberDepartment of Biology, University of Florida, Gainesville, FL USA.
Md Monjurul Islam RifatDepartment of Biology, University of Florida, Gainesville, FL USA.
Fahimeh RahimiDepartment of Biology, University of Florida, Gainesville, FL USA.ORCID 0009-0003-5407-4849
Michael SnyderDepartment of Biology, University of Florida, Gainesville, FL USA.
Amber SinghDepartment of Biology, University of Florida, Gainesville, FL USA.
Benjamin EickwortDepartment of Biology, University of Florida, Gainesville, FL USA.
Yell NewhallDepartment of Biology, University of Florida, Gainesville, FL USA.
Moein RajaeiDepartment of Biology, University of Florida, Gainesville, FL USA.ORCID 0009-0006-7079-2033
Ayush Shekhar SaxenaDepartment of Biology, University of Florida, Gainesville, FL USA.
Robyn E TannyDepartment of Biology, Johns Hopkins University, Baltimore, MD USA.ORCID 0000-0002-0611-3909
Vaishali KatjuDepartment of Ecology and Genetics, Uppsala University, Uppsala, Sweden.ORCID 0000-0003-4720-9007
Erik C AndersenDepartment of Biology, Johns Hopkins University, Baltimore, MD USA.ORCID 0000-0003-0229-9651
Juannan ZhouDepartment of Biology, University of Florida, Gainesville, FL USA.
Charles F BaerDepartment of Biology, University of Florida, Gainesville, FL USA.ORCID 0000-0002-0140-5814

Funding

100K spontaneous mutations: the foundation for an evolutionary systems biology of C. elegansR01GM127433 · NIGMS · UNIVERSITY OF FLORIDA · PI BAER, CHARLES F, KATJU, VAISHALI · 2018 to 2021
$1.3M
Modeling non-additive genetic mechanisms for complex traitsR35GM154908 · NIGMS · UNIVERSITY OF FLORIDA · PI Juannan Zhou · 2024 to 2026
$1.0M
NIGMS NIH HHS R01 GM127433NIGMS NIH HHS R35 GM154908
6 · The paper itself

Abstract

The rate, molecular spectrum, and fitness effects of mutations vary at all levels of the biological hierarchy, from within individual genomes to among taxonomic domains. Understanding the evolutionary factors underpinning that variation is of fundamental importance to biology. Accurate quantification of the properties of mutations requires that other evolutionary forces, especially natural selection, be minimized as much as possible. To investigate the evolution of the mutational process in

Indexed as

Cost of fidelityDistribution of fitness effectsDrift barrierEpistasisMutation accumulationMutational biasMutation rateMutation spectrum

Identifiers

PMID41676472
PMCPMC12889430

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.