Evidence map›Paper›PMID 41676458›Full record

ArticlebioRxiv : the preprint server for biology2026

Structural Mechanisms of SAMD9 Autoinhibition and Pathogenic Dysregulation.

Zongjun Mou, Fushun Zhang, Marisol Morales, Bibekananda Sahoo, Xinghong Dai, Yan Xiang

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zongjun MouDepartment of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Fushun ZhangDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. & Teresa Lozano Long School of Medicine, The University of Texas at San Antonio, San Antonio, TX 78229, USA.
Marisol MoralesDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. & Teresa Lozano Long School of Medicine, The University of Texas at San Antonio, San Antonio, TX 78229, USA.
Bibekananda SahooDepartment of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Xinghong DaiDepartment of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Yan XiangDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. & Teresa Lozano Long School of Medicine, The University of Texas at San Antonio, San Antonio, TX 78229, USA.

Funding

TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Susan S Padalecki · 1991 to 2026
$59.1M
Novel Translational Control Mechanisms in Host Range Restriction of PoxvirusR01AI151638 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI YAN XIANG · 2020 to 2026
$3.4M
Acquisition of 200kV Glacios Cryo Transmission Electron MicroscopeS10OD032437 · OD · CASE WESTERN RESERVE UNIVERSITY · PI CHAKRAPANI, SUDHA · 2022 to 2022
$2.0M
Molecular basis of plasma membrane rupture in lytic cell death and its inhibition by cytoprotective agent glycineR35GM151043 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI Xinghong Dai · 2023 to 2026
$1.6M
FACSAria Fusion cell sorter for Flow Cytometry Shared ResourceS10OD030432 · OD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BERTON, MICHAEL T · 2022 to 2022
$596k
NCI NIH HHS P30 CA054174NIAID NIH HHS R01 AI151638NIGMS NIH HHS R35 GM151043NIH HHS S10 OD030432NIH HHS S10 OD032437
6 · The paper itself

Abstract

SAMD9 and SAMD9L (SAMD9/9L) are large cytosolic proteins essential for hematopoietic homeostasis and antiviral defense

Identifiers

PMID41676458
PMCPMC12889676

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.