ArticleArchives of medical science : AMS2025
Associations between leisure sedentary behaviors, physical activity, and chronic respiratory diseases: a Mendelian randomization study.
Article in Archives of medical science : AMS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Causal associations between sleep apnea and dementia: a two-sample Mendelian randomization study.Archives of medical science : AMS · 2026Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Chronic respiratory diseases represent a significant global health burden, characterized by high incidence and mortality rates. However, the potential associations between physical activity, leisure sedentary behavior, and susceptibility to chronic respiratory diseases remain uncertain. Material and methods: A two-sample Mendelian randomization approach was used in this investigation, using physical activity and leisure sedentary behavior as exposures, and common chronic respiratory diseases such as asthma, bronchiectasis, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, pulmonary arterial hypertension, and obstructive sleep apnea syndrome as outcomes, to explore the genetic causal relationships. We utilized genome-wide association studies to select genetic instrumental variables related to these exposures. These variables were then used to assess the impact of physical activity and leisure sedentary behavior on the susceptibility to chronic respiratory diseases. Results: Our findings indicate that strenuous sports or other exercises and vigorous physical activity are protective factors against asthma, whereas leisure-time television watching is a risk factor. Frequent leisure-time television watching is closely associated with an increased susceptibility to chronic obstructive pulmonary disease. Leisure-time computer use and overall average acceleration in physical activity are inversely related to the risk of developing pulmonary arterial hypertension. Higher engagement in driving and vigorous physical activity are causally associated with a reduced risk of obstructive sleep apnea syndrome. Conclusions: Our analysis supports the causal relationships between physical activity, sedentary behavior, and chronic respiratory diseases, providing genetic evidence that supports lifestyle modifications to reduce susceptibility to these conditions.
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