Evidence map›Paper›PMID 41676354›Full record

ArticleResearch and practice in thrombosis and haemostasis2026

Extraterrestrial regolith is hemostatic and potentially suitable for hemorrhage control in space.

Nabil Ali-Mohamad, Ting-Hsuan Wang, Lih Jiin Juang, Nuoya Peng, Massimo F Cau, Kevin Cannon, Christian J Kastrup

Abstract read
In one paragraph

Article in Research and practice in thrombosis and haemostasis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Should we consider styptics in patients with bleeding disorders?Research and practice in thrombosis and haemostasis · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nabil Ali-MohamadMichael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.
Ting-Hsuan WangMichael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.
Lih Jiin JuangMichael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.
Nuoya PengVersiti Blood Research Institute, Versiti Wisconsin, Milwaukee, Wisconsin, USA.
Massimo F CauMichael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.
Kevin CannonDepartment of Geology and Geological Engineering, Colorado School of Mines, Golden, Colorado, USA.
Christian J KastrupMichael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Long-duration space missions beyond low Earth orbit pose increased risks of injury to astronauts. Traumatic hemorrhage will be a cause of preventable death. Due to payload constraints, Objectives: Here, we aimed to evaluate whether extraterrestrial regolith simulants, their mineral components, and meteorites can activate coagulation through factor (F)XII and control bleeding. Methods: The procoagulant potential of Lunar and Martian regolith simulants, their component silicate minerals, and meteorite samples was assessed Results: All extraterrestrial regolith simulant samples accelerated clotting, thrombin generation, and FXII activation in normal plasma, with reduced effects in FXII-immunodepleted or FXII-inhibited plasma. Phyllosilicates showed greater procoagulant activity than framework silicates. Conclusion: Extraterrestrial regolith activated coagulation in a FXII-dependent manner and reduced blood loss in a trauma model of penetrating hemorrhage. This suggests that extraterrestrial regolith may be used as a hemostatic agent during space missions.

Indexed as

combat casualty carehemostasisin situ resource utilization (ISRU)intrinsic pathwayspace medicine

Identifiers

PMID41676354
PMCPMC12887395

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.