SynthesisFrontiers in psychology2025
Meta-analysis and systematic review of the impact of different exercise intervention on emotional symptoms in patients with bipolar affective disorders.
Synthesis in Frontiers in psychology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
Objective: This study systematically evaluates the effects of diverse exercise and combined interventions on patients with bipolar disorder (BD), identifies optimal intervention parameters through subgroup analyses, explores dose-response relationships, and delivers evidence-based support for exercise interventions in this population. Methods: Randomized controlled trials (RCTs) examining exercise interventions for BD patients were retrieved from domestic and international databases. Literature screening and data extraction adhered to standard criteria. Study quality was assessed via the Cochrane Risk of Bias Tool 2.0. Meta-analyses were conducted in RevMan 5.4, while subgroup analyses (stratified by intervention type, duration, frequency, and age) and dose-response analyses were performed in Stata 15. The Benjamini-Hochberg method was used to apply false discovery rate (FDR) correction, controlling false positive risks in multiple comparisons (statistical significance was defined as corrected Results: Exercise interventions significantly improved depression, anxiety, and mania symptoms and health questionnaire outcomes in BD patients (all corrected Conclusion: Exercise interventions significantly improve depression, anxiety, and mania symptoms as well as health questionnaire outcomes in BD patients, with exercise combined with psychotherapy or mindfulness training producing superior effects. Improvements in diastolic blood pressure warrant cautious interpretation, as they are supported by only one study. The recommended protocol consists of exercise combined with psychotherapy or mindfulness training, with a duration of ≥12 weeks, 2-3 sessions/week, and single-session length ≤ 90 min; this protocol exerts a positive impact on patients' emotional symptoms. Future RCTs with larger samples and longer follow-up periods are needed to further validate these findings. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251032877, identifier: CRD420251032877.
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