ArticleQuantitative biology (Beijing, China)2026
Mechanistic two-pathway modeling of substrate inhibition in lactic acid bacteria for enhanced fermentation control.
Article in Quantitative biology (Beijing, China), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Integrating Fermentation and Extrusion to Enhance Texture, Stability, and Nutritional Quality of Pigeon Pea (Foods (Basel, Switzerland) · 2026Article
- Mechanistic two-pathway modeling of substrate inhibition in lactic acid bacteria for enhanced fermentation control.Quantitative biology (Beijing, China) · 2026Article
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2 authors.
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Abstract
Substrate inhibition in lactic acid bacteria (LAB) fermentation occurs when substrate concentration exceeds a critical value, leading to reduced cell growth and thus inefficient lactic acid production. Many efforts, including experimental and kinetic models, have been devoted to elucidate the possible mechanisms of substrate inhibition. However, the molecular and physiological basis of this phenomenon remains incompletely characterized. In this study, we propose a mechanistic two-pathway model that integrates a substrate-responsive molecular regulatory pathway into the typical substrate assimilation and microbial growth pathway. Our modeling analysis captures a global growth dynamics, including lag, exponential, and stationary phases over a wide range of initial substrate concentrations, with one set of parameters. Consequently, the results exhibit a significantly prolonged lag phase at high initial substrate concentrations. We test this model framework by combining the model results with the published experimental data of LAB batch fermentation such as
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