Evidence map›Paper›PMID 41676316›Full record

ArticleBlood immunology & cellular therapy2025

Lipid Nanoparticle Fas Gene Therapy Suppresses Autoimmune Lymphoproliferative Syndrome in Mice.

Dakota B Poschel, Zainab Tiamiyu, Priscilla Redd, Alyssa Merting, Natasha Savage, Kebin Liu

Abstract read
In one paragraph

Article in Blood immunology & cellular therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dakota B PoschelDepartment of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA 30912, USA.
Zainab TiamiyuDepartment of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA 30912, USA.
Priscilla ReddDepartment of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA 30912, USA.
Alyssa MertingDepartment of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA 30912, USA.
Natasha SavageDepartment of Pathology, Medical College of Georgia.
Kebin LiuDepartment of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA 30912, USA.

Funding

Role of IRF8 in Tumor Rejection and SuppressionR01CA133085 · NCI · AUGUSTA UNIVERSITY · PI LIU, KEBIN · 2008 to 2019
$2.9M
Development of SUV39H1-selective inhibitor for human colon cancer therapyR01CA278852 · NCI · AUGUSTA UNIVERSITY · PI KEBIN LIU · 2024 to 2026
$1.5M
BLRD VA IS1 BX004009CSRD VA I01 CX001364CSRD VA I01 CX001962NCI NIH HHS R01 CA133085NCI NIH HHS R01 CA278852
6 · The paper itself

Abstract

Autoimmune lymphoproliferative syndrome (ALPS) is a genetic disease of deregulated leukocyte homeostasis caused by

Identifiers

PMID41676316
PMCPMC12890007

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.