ArticleAmerican journal of translational research2026
Targeting the LINC01515/miR-325-3p/ERBB4 axis suppresses gastric cancer progression.
Article in American journal of translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundGlobally, gastric cancer (GC) remains the leading cause of cancer-related death. Research on circular RNAs (circRNAs), microRNAs (miRNAs), and long non-coding RNAs (lncRNAs) is mostly focused on cancer. lncRNAs can influence gene expression by functioning as ceRNAs to sponge miRNAs. This study sought to characterize the expression patterns of miR-325-3p and LINC01515 and investigate their possible mechanisms in GC.
methodsQuantitative real-time polymerase chain reaction (qRT-PCR) was performed to detect miR-325-3p expression. The target mRNAs and competitive lncRNAs of miR-325-3p were screened via bioinformatics analysis. Cell counting, Transwell assay, and wound-healing experiments were conducted to measure cell growth, migration, and invasion. The relationships between LINC01515, miR-325-3p, and erythroblastic oncogene B4 (ERBB4) were confirmed through the dual luciferase reporter gene assay.
resultsGC cell lines and tissues showed upregulated LINC01515 and ERBB4 expression, accompanied by downregulated miR-325-3p expression. These expression patterns were associated with tumor proliferation, invasion, and migration. ERBB4 was positively correlated with LINC01515 in the context of differentially expressed miR-325-3p. These findings suggest that LINC01515 may regulate ERBB4 by functioning as a ceRNAs to sponge miR-325-3p.
conclusionLINC01515 upregulates ERBB4 expression in GC by sponging miR-325-3p, thereby promoting tumor growth. These findings highlight the LINC01515/miR-325-3p/ERBB4 axis as a potential therapeutic target for GC.
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