ArticleAmerican journal of translational research2026
Dihydroartemisinin attenuates pemphigus vulgaris by regulating Dsg3 and the TLR9/NF-κB pathway.
Article in American journal of translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
objectiveTo evaluate the therapeutic efficacy of dihydroartemisinin (DHA) in pemphigus vulgaris (PV).
methodsBased on network pharmacology analysis, the TLR9/NF-κB signaling axis was selected as the primary pathway of interest. Skin specimens were first validated using immunohistochemistry. Subsequently, HaCaT cells were incubated. Desmoglein 3 (Dsg3) expression was detected using immunofluorescence staining. Cell viability was evaluated using MTS assay. The expression levels of TLR9, TRAF6, MyD88, p-NF-κB p65, MMP-9, and ADAM10 in HaCaT cells treated with control IgG (C-IgG), PV-IgG, and DHA were then examined by western blotting. Finally, these indicators were evaluated in Kunming mice. The results demonstrated that DHA suppressed PV-IgG - induced Dsg3 internalization and depletion. PV-IgG appeared to activate the NF-κB pathway through TLR9/TRAF6 signaling, while DHA effectively inhibited this effect. Moreover, DHA downregulated the expression of ADAM10 and MMP-9, critical proteases involved in the pathogenesis of PV.
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