ArticleAmerican journal of translational research2026
Integrated single-cell analysis with experimental validation reveals ANXA2 as a therapeutic target for ferroptosis in inflammatory bowel disease.
Article in American journal of translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundInflammatory bowel disease (IBD) is a chronic inflammatory disease characterized by intestinal dysfunction. Ferroptosis is a critical pathogenic mechanism in IBD. However, the therapeutic targets for ferroptosis-related IBD progression remain unclear. Therefore, this study aimed to identify potential therapeutic targets associated with ferroptosis in IBD.
methodsSingle-cell RNA sequencing data (GSE134809) were analyzed using gene set scoring, cell-cell communication, pseudotime analysis, and high-dimensional gene co-expression network analysis (hdWGCNA) to screen for ferroptosis-related targets.
resultsBioinformatic analysis of 28,974 cells identified that fibroblasts, particularly the Fibro_2 subpopulation, were highly associated with ferroptosis, with ANXA2 identified as a core target.
conclusionANXA2 is highly expressed in fibroblasts and is associated with the ferroptosis of IBD, providing a novel therapeutic target for treatment of IBD.
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