ReviewAmerican journal of translational research2026
Effect of exercise intervention on elderly patients with sarcopenia: a meta-analysis.
Review in American journal of translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
3 authors.
Funding
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Abstract
objectiveTo investigate the effects of exercise on muscle mass and strength in elderly sarcopenia patients through a meta-analysis.
methodsRandomized controlled trials (RCTs) on exercise interventions for elderly patients with sarcopenia were retrieved from the Web of Science, PubMed, Cochrane Library, ProQuest, EBSCOhost, Scopus, EMBASE, China National Knowledge Infrastructure (CNKI), and Chinese Science and Technology Periodical Database (VIP) published between 2015 and 2025. The Cochrane Risk of Bias tool was used to assess the quality of studies, and the RevMan 5.3 software was applied for the meta-analysis. Subgroup analyses were performed to evaluate the effect of different exercise intervention protocols on the outcome measures.
resultsA total of 15 studies involving 902 participants were included in this study, with 527 receiving exercise intervention. Meta-analysis results indicated that exercise intervention significantly improved skeletal muscle index (MD = 0.25, 95% CI: 0.13-0.39), knee extension strength (KES) (SMD = 0.64, 95% CI: 0.46-0.81), walking speed (SMD = 0.54, 95% CI: -0.10 to 1.18), TUG (MD = -1.38, 95% CI: -1.73 to -1.02), and handgrip strength (SMD = 0.52, 95% CI: 0.29 to 0.75). Subgroup analysis of the modality and frequency of exercise intervention for the measure of handgrip strength indicated that both RT and AT+RT increased handgrip strength in elderly sarcopenic patients without any significant between-group difference. Both exercise frequency of ≥ 3 times/week and < 3 times/week showed an improvement in handgrip strength.
conclusionExercise interventions can increase muscle mass and strength in people suffering from sarcopenia and enhance their quality of life. Nonetheless, additional research is required to confirm these results and refine specific protocols for implementation.
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