ArticleAmerican journal of translational research2026
Multimodal optical coherence tomography and angiography and serologic markers for accurate early diagnosis of dysthyroid optic neuropathy.
Article in American journal of translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the value of optical coherence tomography (OCT) and OCT angiography (OCTA) for the early diagnosis of dysthyroid optic neuropathy (DON) in patients with thyroid-associated orbitopathy (TAO).
methodsThis retrospective study (2022-2024) included 52 TAO eyes (22 DON, 30 non-DON) and 52 healthy controls. OCT/OCTA scans evaluated structural features (ganglion cell complex, peripapillary retinal nerve fiber layer, Bruch's membrane opening-minimum rim width [BMO-MRW]) and vascular features (superficial retinal capillary plexus [SRCP] density, choroidal capillary vascular density, foveal avascular zone [FAZ] area). Contrast sensitivity function (CSF), thyroid peroxidase antibody (TPOAb) status, and glutamate levels were also analyzed. Multivariate logistic regression identified risk factors, and receiver operating characteristic curves evaluated diagnostic performance.
resultsMost structural OCT features showed no significant differences, except CSF, which was significantly reduced in DON eyes (P < 0.001). Vascular features such as SRCP density and choroidal capillary density decreased progressively in DON, while FAZ area was significantly larger (all P < 0.001). TPOAb positivity and glutamate levels were highest in the DON group (P < 0.001). Multivariate analysis identified SRCP density, FAZ area, TPOAb positivity, and glutamate concentration as independent risk factors for DON. A combined model of BMO-MRW and subfoveal choroidal thickness achieved the highest diagnostic accuracy (AUC = 0.940, sensitivity = 88.0%, specificity = 90.0%).
conclusionsMultimodal imaging combining OCT and OCTA features improves the sensitivity and specificity of early DON diagnosis, offering a reliable, noninvasive screening approach for clinical practice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.