ArticleArchives in cancer research2015
Association between Mitochondrial Bioenergetics and Radiation-Related Fatigue: A Possible Mechanism and Novel Target.
Article in Archives in cancer research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
5 citing papers in PubMed.
- Exploring Biologic Correlates of Cancer-Related Fatigue in Men With Prostate Cancer: Cell Damage Pathways and Oxidative Stress.Biological research for nursing · 2020Article
- Relationships between expression ofCancer management and research · 2019Article
- Integrated mitochondrial function and cancer-related fatigue in men with prostate cancer undergoing radiation therapy.Cancer management and research · 2018Article
- Symptoms predicting health-related quality of life in prostate cancer patients treated with localized radiation therapy.Family medicine and community health · 2017Article
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Background: Fatigue is one of the cancer symptoms most often reported by patients receiving radiation therapy (XRT). Understanding the mechanism behind the development of cancer-related fatigue will enable the design of novel interventions for radiation-induced fatigue. This research proposal is designed to determine the association between mitochondrial bioenergetics and fatigue in prostate cancer patients receiving XRT. Methods and Results: We proposed a mechanism of mitochondrial bioenergetics for cancer-related fatigue based on a molecular-genetic approach, linking impaired ATP production as a consequence of XRT. This prospective, hypothesis-testing project uses a matched case-control, repeated-measures design. Peripheral blood will be collected from each subject at 3 timepoints (baseline, midpoint, and endpoint) to determine mitochondrial bioenergetics profile. Fatigue will be measured using validated questionnaires (The Conclusion: Our hypothesis provides a mechanism for impaired ATP production as a major consequence of XRT that leads to debilitating radiation-induced fatigue. Implications for Practice: The results have the potential to identify targets for pharmacological and, in particular, nutraceutical interventions and initiate a new direction for design of interventions for cancer-related fatigue.
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Registered trials
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