ArticleACS catalysis2026
Oxidative Rearrangement of Indoles Enabled by Promiscuous Cryptic Halogenation with Vanadium-Dependent Haloperoxidases.
Article in ACS catalysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Bromination of Cannabinoids fromOrganic letters · 2026Article
- Biocatalytic Synthesis of Isoxazolines Enabled by Cryptic Nitrile Oxide Formation by a Vanadium-Dependent Chloroperoxidase.Angewandte Chemie (International ed. in English) · 2026Article
- Chemoenzymatic Triazolopyridine Synthesis Enabled by Cryptic Diazo Formation by Vanadium-Dependent Haloperoxidases.Organic letters · 2026Article
- Elevating Haloperoxidase Expression in Escherichia coli through Fusion with a Formate Oxidase.Chembiochem : a European journal of chemical biology · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The 2-oxindole class of heterocycles are privileged structural components in natural products and biologically active compounds. One of the most attractive methods for accessing 2-oxindoles is through direct oxidation of indoles, but current methods rely on the use of chemical oxidizing agents that lead to the generation of harmful waste products or biocatalytic methods using enzymes with a limited substrate scope. Herein, we describe the development and application of a general biocatalytic platform for the oxidative rearrangement of indoles using enzymatic halide recycling with vanadium-dependent haloperoxidases (VHPOs) facilitated by a catalytic quantity of halide salt and hydrogen peroxide as the terminal oxidant. This catalytic system is effective for the oxidative rearrangement of indoles into 2-oxindoles and 2-spirooxindoles. The developed protocol has been applied in multienzymatic and chemoenzymatic synthesis, late-stage functionalization of biologically active molecules, tryptophan-selective peptide modification, and gram-scale syntheses of coerulescine and horsfiline.
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