Evidence map›Paper›PMID 41676151›Full record

ReviewFrontiers in immunology2026

Outer membrane vesicles as a versatile nanoplatform for advanced vaccine development and immunotherapy.

Jiawen Zhang, Yuhang Zhi, Yu Lu, Fang Ma

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jiawen ZhangInstitute of Veterinary Immunology & Engineering, National Research Center of Engineering and Technology for Veterinary Biologicals, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
Yuhang ZhiInstitute of Veterinary Immunology & Engineering, National Research Center of Engineering and Technology for Veterinary Biologicals, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
Yu LuInstitute of Veterinary Immunology & Engineering, National Research Center of Engineering and Technology for Veterinary Biologicals, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
Fang MaInstitute of Veterinary Immunology & Engineering, National Research Center of Engineering and Technology for Veterinary Biologicals, Jiangsu Academy of Agricultural Sciences, Nanjing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacterial outer membrane vesicles (OMVs) are nano-sized, lipid-bilayer vesicles naturally released by Gram-negative bacteria. These vesicles are enriched with diverse biomolecules, including lipids, proteins, and nucleic acids, enabling them to mediate critical biological processes. Emerging evidence highlights their pivotal roles in bacterial physiology, intercellular communication, and environmental adaptation, alongside their promising therapeutic potential. This review focuses on recent advances in OMV biogenesis, composition, function and applications. By integrating current knowledge, we aim to inspire novel insights into the molecular mechanisms underlying OMV functions and facilitate their translational development in medicine. Ultimately, this work serves as a comprehensive reference to accelerate future research and clinical utilization of this versatile platform.

Indexed as

Bacterial Outer MembraneBacterial Outer Membrane ProteinsGram-Negative BacteriaImmunotherapyVaccine DevelopmentAnimalsHumansBacterial Outer Membrane Proteinsbacterial outer membrane vesiclebioengineering applicationsimmune modulationnanoscale vesiclestarget delivery

Identifiers

PMID41676151
PMCPMC12886038

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.