Evidence map›Paper›PMID 41676088›Full record

ArticleFrontiers in medicine2026

Diagnostic accuracy and safety of Diaskintest

Afrânio Kritski, Carla Conceição, Martha Oliveira, Ana Paula Razal Dalvi, Marcelo Cordeiro-Santos, Adriana Rezende Moreira, Aline Lopes, Rogerio Ruffino, Luciana Rodrigues, Eliene Mesquita and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Afrânio KritskiHospital Universitário Clementino Fraga Filho/Instituto de Doenças do Tórax, Escola de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Carla ConceiçãoHospital Universitário Clementino Fraga Filho/Instituto de Doenças do Tórax, Escola de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Martha OliveiraHospital Universitário Clementino Fraga Filho/Instituto de Doenças do Tórax, Escola de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Ana Paula Razal DalviHospital Universitário Clementino Fraga Filho/Instituto de Doenças do Tórax, Escola de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Marcelo Cordeiro-SantosFundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil.
Adriana Rezende MoreiraHospital Universitário Clementino Fraga Filho/Instituto de Doenças do Tórax, Escola de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Aline LopesHospital Universitário Clementino Fraga Filho/Instituto de Doenças do Tórax, Escola de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Rogerio RuffinoHospital Universitário Pedro Ernesto, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
Luciana RodriguesHospital Universitário Pedro Ernesto, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
Eliene MesquitaInstituto Ary Parreiras State, State Health Secretariat of Rio de Janeiro, Niterói, Brazil.
Sergian Vianna CardozoSchool of Medicine, Universidade do Grande Rio Professor José de Souza Herdy, Duque de Caxias, Brazil.
Maria Jose Fernandes PereiraServiço de Atenção Especializada em Tuberculose, Municipal Health Secretariat of Itaboraí, Itaboraí, Brazil.
Sumire SakabeCentro de Referência e Treinamento DST-AIDS-SP, São Paulo, Brazil.
Anete TrajmanHospital Universitário Clementino Fraga Filho/Instituto de Doenças do Tórax, Escola de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Marcela BheringHospital Universitário Clementino Fraga Filho/Instituto de Doenças do Tórax, Escola de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Evidence on the accuracy and safety of the ESAT-6/CFP-10-based Diaskintest Method: A double-blind randomized clinical trial was conducted at eight centers in Brazil between July 2023 and September 2024. Participants were allocated to the TB group (microbiologically confirmed pulmonary TB), in whom sensitivity was estimated, and the control group (healthy, unexposed adults), in whom specificity was estimated using the QuantiFERON-TB Plus Results: A total of 337 controls and 136 TB participants were enrolled. TST showed higher sensitivity than both Diaskintest and QFT-plus (0.84 [95% CI 0.76-0.90] vs. 0.68 [95% CI 0.59-0.76], and 0.63 [95% CI 0.54-0.72], respectively). Diaskintest Conclusion: TST had greater sensitivity than Diaskintest Clinical trial registration: https://ensaiosclinicos.gov.br/, identifier RBR-7tn2ysw.

Indexed as

diagnosislatent tuberculosis infectionrecombinant proteintuberculintuberculosistuberculosis-specific skin tests

Identifiers

PMID41676088
PMCPMC12886023

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.