SynthesisFrontiers in bioengineering and biotechnology2025
The efficacy and safety of annulus fibrosus suture as adjuvant therapy for lumbar disc herniation: a systematic review and meta-analysis.
Synthesis in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
Objective: Lumbar disc herniation (LDH) has demonstrated a rising prevalence in contemporary clinical practice, significantly compromising patients' daily lives and potentially necessitating surgical intervention. While annulus fibrosus suture (AFS) techniques are increasingly incorporated into surgical protocols, current evidence remains inconclusive regarding their definitive clinical advantages. Methods: We performed a comprehensive search of eight databases from inception to September 2025 to identify published articles on AFS for LDH. Outcome measures encompassed operative time, incision length, blood loss, length of stay (LOS), visual analog scale (VAS) score, Japanese Orthopedic Association (JOA) score, Oswestry disability index (ODI) score, disc height, recurrence, and complication. The quality of the studies was analyzed using the RoB-2 and ROBINS-I tools. Statistical analyses were performed using RevMan 5.4 software and Stata 17 software. The GRADE approach was used to evaluate the certainty of evidence for outcomes. Results: A total of 58 studies encompassing 5,765 patients diagnosed with LDH. The control group had shorter operative time (MD = 4.85, 95% CI: 2.79 to 6.92, Conclusion: Current evidence suggests that AFS therapy may be advantageous in improving clinical symptoms and may reduce postoperative recurrence. Due to limited data and low quality of evidence, additional large-scale, multicenter trials are needed to verify and strengthen these findings.
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