Evidence map›Paper›PMID 41676055›Full record

ArticleFrontiers in dementia2025

Microglial activation is raised in preclinical Alzheimer's disease and associated with covert memory impairment.

Pernille Louise Kjeldsen, Lasse Stensvig Madsen, Peter Parbo, Rola Ismail, Joel Fredrik Astrup Aanerud, Malene Kaasing, Malene Flensborg Damholdt, Simon Fristed Eskildsen, Leif Østergaard, David James Brooks

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in dementia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Pernille Louise KjeldsenDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Lasse Stensvig MadsenDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Peter ParboDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Rola IsmailDepartment of Nuclear Medicine, Vejle Hospital, Vejle, Denmark.
Joel Fredrik Astrup AanerudDepartment of Nuclear Medicine and PET, Aarhus University Hospital, Aarhus, Denmark.
Malene KaasingDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Malene Flensborg DamholdtDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Simon Fristed EskildsenDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Leif ØstergaardDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.
David James BrooksDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Alzheimer's disease (AD) is a continuum between normal health and dementia with a long preclinical phase, during which AD pathologies start to emerge, but where there are not yet any overt symptoms. The hallmark pathologies of AD are extracellular Methods: A total of 19 preclinical AD subjects with no cognitive complaints but abnormal Aβ deposition present on Results: Microglial activation was raised in occipital and parietal cortices in preclinical AD subjects compared to healthy controls ( Conclusion: Microglial activation was significantly raised in preclinical AD cases with no cognitive complaints and associated with impaired memory test performance. This suggests that microglial activation is present before overt clinical symptoms emerge and may be detrimental to cognition even at this early stage.

Indexed as

Alzheimer’s diseaseamyloidcognitionmemorymicrogliaPET

Identifiers

PMID41676055
PMCPMC12885982

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.