ArticleNPJ cardiovascular health2025
Loneliness associates with endothelial dysfunction in a community-based cohort: a pilot study and translational approach.
Article in NPJ cardiovascular health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Social Isolation, Loneliness and Subclinical Atherosclerosis.Current atherosclerosis reports · 2026Review
- Loneliness and cognitive aging: a brain-heart axis perspective on a modifiable risk.Frontiers in aging · 2026Review
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Loneliness is known to be an important contributor to cardiovascular disease (CVD). However, little is known about the impact of loneliness on endothelial barrier integrity, a crucial hallmark of CVD development and progression. In this study, we aimed to investigate how loneliness might impact the endothelium. We found greater perceived loneliness associated with the product of circulating epinephrine and TNFα (E/T), which, in turn, associated with lower VE-cadherin on endothelial cells in an ex vivo experiment. Additionally, circulating plasma levels of soluble VE-cadherin were associated significantly with subclinical CVD. To explore the mechanistic aspects of these associations, we measured the effects of E/T on endothelial barrier function in vitro. E/T treatment decreased endothelial VE-cadherin expression and dampened endothelial barrier integrity, involving at least partial JAK/Stat signaling, highlighting a potential additive effect of epinephrine and TNFα on endothelial dysfunction, potentially accelerating CVD development and progression in individuals experiencing loneliness-related chronic stress.
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Registered trials
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