ArticleBiochemistry and biophysics reports2026
Comprehensive multi-omics analysis reveals RUNX1's prognostic value, immune associations, and MUC13-Mediated mechanistic role in hepatocellular carcinoma pathogenesis.
Article in Biochemistry and biophysics reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Hepatocellular carcinoma (HCC) is a biologically and clinically heterogeneous malignancy, posing major challenges for early diagnosis, prognostic prediction, and therapeutic intervention. The Runt-related transcription factor (RUNX) family, comprising RUNX1, RUNX2, and RUNX3, plays essential roles in cellular processes and contribute to the pathogenesis of numerous malignancies. This study aims to elucidate their role in tumor progression and its clinical implications. We performed an integrative pan-cancer multi-omics analysis across 33 cancer types to characterize RUNX family expression patterns, prognostic associations, and immune correlations using publicly available datasets. Expression and functional roles were experimentally validated in HCC through
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