ArticleAnnals of medicine and surgery (2012)2026
Incidence and predictors of recurrent stroke in patients with cryptogenic stroke later diagnosed with atrial fibrillation: a 5-year cohort study from a tertiary care hospital.
Article in Annals of medicine and surgery (2012), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Cryptogenic stroke (CS) accounts for a substantial proportion of ischemic strokes, with atrial fibrillation (AF) often identified as the underlying cause. In countries with low-resource settings like Pakistan, limited access to extended cardiac monitoring delays AF detection, increasing the risk of recurrent stroke. Objective: To determine the incidence and predictors of recurrent ischemic stroke in patients initially diagnosed with CS and later diagnosed with AF at a tertiary care hospital in Pakistan. Methods: A retrospective cohort study was conducted at tertiary care Hospital, from January 2018 to December 2023. Adult patients with CS and a subsequent diagnosis of AF within 12 months were included. Data on demographics, diagnostic modality, echocardiography, anticoagulation adherence, and outcomes were collected. Cox regression was used to identify independent predictors of recurrent stroke. Results: Out of 406 patients with CS, 109 (26.8%) were later diagnosed with AF. Recurrent ischemic stroke occurred in 32 patients (29.4%) over a median follow-up of 13.8 months. Only 11 of the recurrent cases (34.4%) were on anticoagulation therapy at the time of recurrence. Multivariate analysis identified age >65 years (HR: 2.21; 95% CI: 1.18-4.14), delayed AF detection beyond 6 months (HR: 2.58; 95% CI: 1.36-4.91), non-adherence to anticoagulation (HR: 3.44; 95% CI: 1.88-6.27), and left atrial enlargement (HR: 2.03; 95% CI: 1.15-3.57) as independent predictors of recurrence. Mortality (18.8%) and functional disability (mRS >3 in 59.3%) were significantly higher in the recurrence group. Conclusion: Delayed AF detection and poor anticoagulation adherence significantly increase the risk of recurrent stroke in CS-AF patients. Prolonged cardiac monitoring and improved access to anticoagulants, particularly NOACs, are essential to reduce recurrent stroke burden in low-resource settings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.