Evidence map›Paper›PMID 41675733›Full record

ReviewAnnals of medicine and surgery (2012)2026

Evaluating mortality burden of diabetes mellitus and peripheral arterial disease in the United States: insights from 26 years of national data.

Ghazi Uddin Ahmed, Usha Kumari, Yogita Kumari, Soni Rani, Beesham Kumar Lohana, Akshy Kumar, Aniket Tara, Sahil Raj, Payal Kumari, Nikeeta Bai and 2 more

Abstract readReview
In one paragraph

Review in Annals of medicine and surgery (2012), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ghazi Uddin AhmedDepartment of Medicine, Jinnah Sindh Medical University, Karachi, Pakistan.
Usha KumariDepartment of Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan.
Yogita KumariDepartment of Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan.
Soni RaniDepartment of Medicine, Khairpur Medical College, Khairpur, Pakistan.
Beesham Kumar LohanaDepartment of Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan.
Akshy KumarDepartment of Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan.
Aniket TaraDepartment of Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan.
Sahil RajDepartment of Medicine, Bahria University Medical and Dental college, Karachi, Pakistan.
Payal KumariDepartment of Medicine, Bahria University Medical and Dental college, Karachi, Pakistan.
Nikeeta BaiDepartment of Medicine, Khairpur Medical College, Khairpur, Pakistan.
Rehma Binte NasirDepartment of Medicine, Shaheed Mohtarma Benazir Bhutto Medical College Lyari, Karachi, Pakistan.
Salih Abdella YusufDepartment of Medicine, Hawassa University, Hawassa, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Diabetes mellitus (DM) and peripheral arterial disease (PAD) are major contributors to mortality across the United States. Monitoring long-term mortality trends and demographic disparities is essential for guiding public health strategies aimed at high-risk populations. Methods: This retrospective analysis utilized mortality data from the CDC Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) database, covering the years 1999 through 2024. Deaths in which DM (ICD-10: E10-E14, O24, P70.2) and PAD (ICD-10: I70-I78) were documented as either primary or contributing causes were included. Age-adjusted mortality rates (AAMRs) per 100 000 people were calculated and stratified by year, gender, race/ethnicity, state, and urban-rural classification. Joinpoint regression analysis was used to identify significant changes in AAMR trends, quantified as annual percent changes. Results: A total of 274 117 deaths among individuals aged 15 and older were linked to both DM and PAD. Nationally, AAMR decreased from 4.3 in 1999 to 2.2 in 2024. Men consistently had higher AAMRs (3.9) than women (2.5). Among racial/ethnic groups, non-Hispanic American Indian or Alaska Native populations had the highest mortality rate (5.2). States such as West Virginia, Oklahoma, California, Vermont, and Ohio had the greatest AAMRs. Rural (nonmetropolitan) areas had higher rates (3.6) than metropolitan regions (3.0). Conclusions: Despite overall reductions in mortality, disparities by sex, race/ethnicity, and geography persist. The objective of this study was to explicitly assess long-term mortality trends and demographic disparities associated with DM and PAD in the United States, providing evidence to guide future preventive and policy measures. These results underscore the importance of targeted and equity-driven health interventions to reduce the burden of DM and PAD nationwide.

Indexed as

CDC WONDERdiabetes mellitusmortality trendsperipheral arterial diseaseunited states

Identifiers

PMID41675733
PMCPMC12889316

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.