ArticleiMetaOmics2025
Circulating metabolomic profile of the MIND diet and its relation to cognition in middle-aged and older adults.
Article in iMetaOmics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed.
- Characterization of a metabolomics signature of the brain-health-promoting MIND diet in older persons.The journal of prevention of Alzheimer's disease · 2026Article
- Artificial intelligence driven diet-intestinal microbiota-host health integration: A four-dimensional paradigm for advancing host wellness research.iMetaOmics · 2026Review
- Association between Accelerometer-derived Physical Activity-related Metabolic Signature and Stroke: A Cohort Study from UK Biobank.The journal of nutrition, health & aging · 2026Article
- A seven-year longitudinal study of the Alzheimer's disease blood metabolome.medRxiv : the preprint server for health sciences · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
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Abstract
The Mediterranean-DASH Diet Intervention for Neurodegenerative Delay (MIND) diet has been related to a lower risk of dementia and better cognitive function. This study identified 47 circulating metabolites associated with the alternate MIND diet score (aMIND) in the UK Biobank (45,906 participants, 168 metabolites measured) and Whitehall II (6193 participants, 152 metabolites measured). Unsaturated fatty acids showed the strongest positive associations with the aMIND, and very low-density lipoprotein measures and glycoprotein acetyls showed the strongest inverse associations. We constructed a metabolomic signature score (MIND-MetS) to objectively reflect MIND diet adherence. Both aMIND and MIND-MetS were associated with better cognitive outcomes in participants aged 55 years or older, and the MIND-MetS partially mediated the aMIND-cognition associations. In summary, the rapid and widely accessible nuclear magnetic resonance-based metabolomic measure could objectively reflect MIND diet adherence. Moreover, our findings offered insights into the intricate connections among diet, metabolism, and cognition.
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Registered trials
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