Evidence map›Paper›PMID 41675697›Full record

ReviewiMetaOmics2025

MicroRNA-microbiota interactions: Emerging strategies for modulating intestinal homeostasis and enhancing host health.

Tianle He, Jiaying Ma, Shuai Liu, Boyan Ma, Jingtao You, Jingjun Wang, Mengmeng Li, Wei Wang, Ya Jing Wang, Shengli Li and 1 more

Abstract readReview
In one paragraph

Review in iMetaOmics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tianle HeState Key Laboratory of Animal Nutrition and Feeding, International Calf and Heifer Organization, College of Animal Science and Technology China Agricultural University Beijing China.ORCID 0000-0001-5173-589X
Jiaying MaState Key Laboratory of Animal Nutrition and Feeding, International Calf and Heifer Organization, College of Animal Science and Technology China Agricultural University Beijing China.ORCID 0000-0002-0027-9932
Shuai LiuState Key Laboratory of Animal Nutrition and Feeding, International Calf and Heifer Organization, College of Animal Science and Technology China Agricultural University Beijing China.ORCID 0000-0001-8732-9754
Boyan MaState Key Laboratory of Animal Nutrition and Feeding, International Calf and Heifer Organization, College of Animal Science and Technology China Agricultural University Beijing China.ORCID 0009-0004-8308-3055
Jingtao YouState Key Laboratory of Animal Nutrition and Feeding, International Calf and Heifer Organization, College of Animal Science and Technology China Agricultural University Beijing China.ORCID 0009-0003-9259-8520
Jingjun WangState Key Laboratory of Animal Nutrition and Feeding, International Calf and Heifer Organization, College of Animal Science and Technology China Agricultural University Beijing China.ORCID 0000-0002-5262-2157
Mengmeng LiState Key Laboratory of Animal Nutrition and Feeding, International Calf and Heifer Organization, College of Animal Science and Technology China Agricultural University Beijing China.ORCID 0000-0001-5958-0941
Wei WangState Key Laboratory of Animal Nutrition and Feeding, International Calf and Heifer Organization, College of Animal Science and Technology China Agricultural University Beijing China.ORCID 0000-0002-9138-9052
Ya Jing WangState Key Laboratory of Animal Nutrition and Feeding, International Calf and Heifer Organization, College of Animal Science and Technology China Agricultural University Beijing China.ORCID 0000-0002-3605-8437
Shengli LiState Key Laboratory of Animal Nutrition and Feeding, International Calf and Heifer Organization, College of Animal Science and Technology China Agricultural University Beijing China.ORCID 0009-0005-2002-5074
Zhijun CaoState Key Laboratory of Animal Nutrition and Feeding, International Calf and Heifer Organization, College of Animal Science and Technology China Agricultural University Beijing China.ORCID 0000-0002-5519-9462

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long-term artificial selection and environmental shifts have driven adaptive changes in both the host genome and the intestinal microbiota. The complex symbiotic relationship between these two has become essential for maintaining intestinal homeostasis and overall health. Concurrently, advancements in sequencing technology and the functional annotation of noncoding RNAs, particularly microRNAs (miRNAs), have facilitated the exploration of mechanisms regulating intestinal homeostasis. Herein, we systematically update the role of miRNA-microbiota interactions in regulating the intestinal barrier, intestinal immunity, changes in intestinal microbiota dynamics, and maintenance of intestinal homeostasis, and we further critically discuss the role of miRNA-microbiota interactions in the maintenance of host intestinal health, metabolic regularity, brain function, and neurodegenerative disease-related disorders. Finally, we highlight the prospects and therapeutic strategies regarding miRNA-microbiota interactions in humans and animals in the context of intestinal microbiota and gene function studies. This study provides a comprehensive overview of miRNA-microbiota interactions and their influence on intestinal homeostasis and host health and offers novel therapeutic strategies for future personalized prevention and treatment of intestinal diseases.

Indexed as

host healthintestinal homeostasisintestinal immunitymicroRNA–microbiota interactions

Identifiers

PMID41675697
PMCPMC12806538

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.