Evidence map›Paper›PMID 41675577›Full record

ArticleNon-coding RNA research2026

DICER1 dysregulation triggers reprogramming of a specific miRNA subset, promotes mesenchymal cell fates and slows TNBC tumorigenic phenotypes.

Ganesh Koshre, Misbah Khan, Swetha Rajasekaran, Amity L Manning, James A Walker, Wayne O Miles

Abstract read
In one paragraph

Article in Non-coding RNA research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ganesh KoshreDepartment of Cancer Biology and Genetics, Ohio State University, Columbus, OH, 43210, USA.
Misbah KhanDepartment of Cancer Biology and Genetics, Ohio State University, Columbus, OH, 43210, USA.
Swetha RajasekaranDepartment of Cancer Biology and Genetics, Ohio State University, Columbus, OH, 43210, USA.
Amity L ManningDepartment of Biology and Biotechnology, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA, 01609, USA.
James A WalkerCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA.
Wayne O MilesDepartment of Cancer Biology and Genetics, Ohio State University, Columbus, OH, 43210, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DICER1 is a key processing enzyme required for the generation of mature and active miRNAs. Mutations that diminish DICER1 function result in widespread changes in miRNA levels, resulting in changes in the transcriptome and cellular phenotypes. Previously, we have found that mutations within the 3'UTR of the

Indexed as

DICER1miR-30dSNAILTNBC tumorigenesisTranscription

Identifiers

PMID41675577
PMCPMC12887731

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.