ArticleNature physics2024
Energy partitioning in the cell cortex.
Article in Nature physics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- State-dependent energy conversion produces degenerate dissipation in active actomyosin networks.bioRxiv : the preprint server for biology · 2026Article
- Topological control of spontaneous failure in active nematic solids.Nature materials · 2026Article
- Diversity in emergent cell locomotion from the coupling cytosolic and cortical Marangoni flows with reaction-diffusion dynamics.PLoS computational biology · 2026Article
- Distinct impact of PI(4)P flux on PI(4,5)PProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Single-cell chiral symmetry breaking under confinement.bioRxiv : the preprint server for biology · 2026Article
- Actin network heterogeneity tunes activator-inhibitor dynamics at the cell cortex.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- 3D pattern formation of a protein-membrane suspension.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A minimal mathematical model for polarity establishment and centralspindlin-independent cytokinesis.Journal of cell science · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
Living systems are driven far from thermodynamic equilibrium through the continuous consumption of ambient energy. In the cell cortex, this energy is invested in the formation of diverse patterns in chemical and mechanical activities, whose spatial and temporal dynamics determine the cell phenotypes and behaviours. How cells partition internal energy between these activities is unknown. Here we measured the entropy production rate of both chemical and mechanical subsystems of the cell cortex across a variety of patterns as the system is driven further from equilibrium. We do this by manipulating the Rho GTPase pathway, which controls the cortical actin filaments and myosin-II. At lower levels of GTPase-activating protein expression, which produce pulses or choppy Rho and actin filament waves, energy is proportionally partitioned between the two subsystems and is subject to the constraint of Onsager reciprocity. Within the range of reciprocity, the entropy production rate is maximized in choppy waves. As the cortex is driven into labyrinthine or spiral travelling waves, reciprocity is broken, marking an increasingly differential partitioning of energy and an uncoupling of chemical and mechanical activities. We further demonstrate that energy partitioning and reciprocity are determined by the competing timescales between chemical reaction and mechanical relaxation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.