Evidence map›Paper›PMID 41675543›Full record

ArticleiMetaOmics2024

TCfinder: Robust tumor cell discrimination in scRNA-seq based on gene pathway activity.

Chenxu Wu, Wei Ning, Tao Wu, Jing Chen, Huizi Yao, Ziyu Tao, Xiangyu Zhao, Kaixuan Diao, Jinyu Wang, Weiliang Wang and 3 more

Abstract readLetter
In one paragraph

Article in iMetaOmics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chenxu WuSchool of Life Science and Technology ShanghaiTech University Shanghai China.ORCID https://orcid.org/0009-0005-7257-4470
Wei NingMilitary Medical Innovation Center Air Force Medical University Xi'an China.
Tao WuSchool of Life Science and Technology ShanghaiTech University Shanghai China.
Jing ChenSchool of Life Science and Technology ShanghaiTech University Shanghai China.
Huizi YaoSchool of Life Science and Technology ShanghaiTech University Shanghai China.
Ziyu TaoSchool of Life Science and Technology ShanghaiTech University Shanghai China.
Xiangyu ZhaoSchool of Life Science and Technology ShanghaiTech University Shanghai China.
Kaixuan DiaoSchool of Life Science and Technology ShanghaiTech University Shanghai China.
Jinyu WangSchool of Life Science and Technology ShanghaiTech University Shanghai China.
Weiliang WangDepartment of Dermatology Yangjiang People's Hospital affiliated to Guangdong Medical University Yangjiang China.
Xinxing LiDepartment of Colorectal Surgery Fudan University Shanghai Cancer Center Shanghai China.
Qianqian SongCenter for Cancer Genomics and Precision Oncology, Wake Forest Baptist Comprehensive Cancer Center Atrium Health Wake Forest Baptist Winston-Salem North Carolina USA.
Xue-Song LiuSchool of Life Science and Technology ShanghaiTech University Shanghai China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

TCfinder is a tumor cell identification tool, based on pathway activity and deep neural network (DNN). Across different platforms of scRNA-seq datasets, TCfinder demonstrates robust identification efficiency. It outperforms existing tumor cell identification tools and performs under sparse data. TCfinder is freely available as an R package at: https://github.com/XSLiuLab/TCfinder.

Identifiers

PMID41675543
PMCPMC12806553

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.