Evidence map›Paper›PMID 41675500›Full record

Trial reportFrontiers in immunology2025

Moving for optimal immunity: the effect of acute high-intensity interval training on phenotype, virus specificity and chemokine receptor expression in human CD8+ T cells.

Katharina Leuchte, Thy Viet Luu, Sara Fresnillo Saló, Kasper Madsen, Lise Heide-Ottosen, Signe Koggersbøl Skadborg, Janine Sophie Kemming, Morten Orebo Holmström, Hongjin Chen, Lars Rønn Olsen and 5 more

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Katharina LeuchteNational Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital Herlev, Herlev, Denmark.
Thy Viet LuuNational Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital Herlev, Herlev, Denmark.
Sara Fresnillo SalóNational Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital Herlev, Herlev, Denmark.
Kasper MadsenNational Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital Herlev, Herlev, Denmark.
Lise Heide-OttosenDepartment of Oncology, Copenhagen University Hospital Herlev, Herlev, Denmark.
Signe Koggersbøl SkadborgDepartment of Health Technology, Section of Experimental and Translational Immunology, Technical University of Denmark, Kongens Lyngby, Denmark.
Janine Sophie KemmingDepartment of Health Technology, Section of Experimental and Translational Immunology, Technical University of Denmark, Kongens Lyngby, Denmark.
Morten Orebo HolmströmNational Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital Herlev, Herlev, Denmark.
Hongjin ChenDepartment of Health Technology, Bioinformatics, Single Cell Omics, Technical University of Denmark, Kongens Lyngby, Denmark.
Lars Rønn OlsenDepartment of Health Technology, Bioinformatics, Single Cell Omics, Technical University of Denmark, Kongens Lyngby, Denmark.
Anders VintherDepartment of Physiotherapy and Occupational Therapy, Copenhagen University Hospitals Herlev and Gentofte, Herlev, Denmark.
Mads Hald AndersenNational Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital Herlev, Herlev, Denmark.
Sine Reker HadrupDepartment of Health Technology, Section of Experimental and Translational Immunology, Technical University of Denmark, Kongens Lyngby, Denmark.
Per Thor Straten *National Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital Herlev, Herlev, Denmark.
Gitte Holmen Olofsson *National Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital Herlev, Herlev, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Physical activity induces rapid and selective leukocyte mobilization. Among the most responsive cell types to high-intensity exercise are CD8 Methods: We assessed the effects of a supervised, group-based HIIT session on the CD8+ T cell compartment in 23 healthy participants. Blood was collected at baseline, immediately post-exercise (ex02), and one hour post-exercise (ex60). CD8 Results: A single HIIT bout induced robust CD8 Discussion: In conclusion, acute HIIT mobilizes functional, virus-reactive CD8

Indexed as

CD8-Positive T-LymphocytesHigh-Intensity Interval TrainingReceptors, ChemokineAdultFemaleHumansMalePhenotypeYoung AdultReceptors, Chemokineacute exerciseadaptive immunitychemokineendurance exerciseexercise immunologyphysical activity

Identifiers

PMID41675500
PMCPMC12888222

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.