ArticleFrontiers in immunology2025
Metabolite analysis of
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- A stress responsive protein contributes to pyomelanin biosynthesis and cell wall stress adaptation inFrontiers in microbiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Methods: We employed optical microscopy, electron microscopy, and nuclear division staining to identify the morphological characteristics of the Results: Non-targeted metabolomics analyses reveal an increased secretion of organic acids and their derivatives, lipids and lipid-like molecules, phenolic compounds, phenylpropanoids, polyketides, as well as alkaloids and their derivatives following conidial germination. Compared to Af293-4h supernatant, Af293-12h supernatant induce a significantly stronger inflammatory response in MH-S cells, characterized by the increased expression of inflammatory factors, including IL-1β, TNF-α, CCL/CXCL and MMPs, via the activation of JAK/STAT/AKT and MAPK signaling pathways. Nasal exposure of conidial supernatant in mice can induce lung inflammation, resulting in lung damage and an elevated proportion of inflammatory cells, as well as increased levels of the inflammatory factors such as TNF-α, IL-1β, and IL-6. Conclusion: Our research indicates significant differences in the metabolites of
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.