Evidence map›Paper›PMID 41675446›Full record

ArticleAmerican journal of ophthalmology case reports2026

Bilateral hemorrhagic occlusive retinal vasculitis and panuveitis following intravitreal faricimab injection: A clinicopathologic case study.

Negin Yavari, Ankur Sudhir Gupta, Andreas Mitsios, Jia-Horung Hung, Dalia El-Feky, Celine Dan-Tam Nguyen, Cigdem Yasar, Frances Andrea Anover, Aim-On Saengsirinavin, Azadeh Mobasserian and 9 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of ophthalmology case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Systemic and ocular complications related to intravitreal administration of anti-VEGF agents.Medical hypothesis, discovery & innovation ophthalmology journal · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Negin YavariByers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA, USA.
Ankur Sudhir GuptaByers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA, USA.
Andreas MitsiosDepartments of Ophthalmology and Pathology, Stanford University, Stanford, CA, USA.
Jia-Horung HungByers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA, USA.
Dalia El-FekyByers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA, USA.
Celine Dan-Tam NguyenUT Southwestern Medical School, Dallas, TX, USA.
Cigdem YasarByers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA, USA.
Frances Andrea AnoverByers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA, USA.
Aim-On SaengsirinavinByers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA, USA.
Azadeh MobasserianByers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA, USA.
Amir AkhavanrezayatByers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA, USA.
Osama ElarabyByers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA, USA.
Xiaoyan ZhangByers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA, USA.
Ngoc Trong Tuong ThanByers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA, USA.
Anna Bettina TothByers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA, USA.
Daniel AgarwalSan Luis Obispo Eye Associate, San Luis Obispo, CA, USA.
Jonathan LinDepartments of Ophthalmology and Pathology, Stanford University, Stanford, CA, USA.
Christopher OrByers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA, USA.
Quan Dong NguyenByers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To describe the clinicopathological study of severe bilateral intraocular inflammation following intravitreal (IVT) injection of faricimab in a patient with neovascular age-related macular degeneration (nAMD). Observation: An 80-year-old Caucasian female with bilateral nAMD presented with blurry vision and ocular pain after receiving bilateral IVT injections of faricimab on separate days from different lots. The patient experienced significant reduction in her visual acuity, from 20/40 to counting-fingers in the right eye and from 20/50 to hand-motion in the left eye; intraocular pressure (IOP) was elevated in both eyes at 48 mmHg and 49 mmHg. Anterior segment examination revealed bilateral diffuse mutton-fat keratic precipitates and fundus examination revealed bilateral vitreous opacities. Fluorescein angiography demonstrated optic disc leakage and bilateral hemorrhagic occlusive vasculitis. Following initial management with systemic corticosteroid, a subsequent unilateral subconjunctival dexamethasone implant, and pars plana vitrectomy, ocular inflammation subsided significantly along with the normalization of IOP. Cytology examination of vitreous samples showed the presence of chronic inflammatory cells in the vitreous. Conclusion: The case highlights the clinical presentation, detailed findings, and successful treatment strategy for hemorrhagic occlusive retinal vasculitis and panuveitis induced by IVT injection of faricimab. Cytopathology analysis of vitreous samples provides novel insights regarding inflammatory mechanisms underlying this rare but potentially sight-threatening complication.

Indexed as

Age-related macular edemaCytopathologyFaricimabIntraocular inflammationPanuveitis

Identifiers

PMID41675446
PMCPMC12887652

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.