Netarsudil-associated conjunctival fragility.

Hursuong Vongsachang, Emory Davtyan, Michael M Lin, Lucy Q Shen, Milica A Margeta

Abstract readCase Reports

In one paragraph

Article in American journal of ophthalmology case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hursuong VongsachangDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.

Emory DavtyanBoston University School of Medicine, Boston, MA, USA.

Michael M LinDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.

Lucy Q ShenDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.

Milica A MargetaDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.

Funding

Mechanisms of microglial neuroinflammatory response in glaucomaR01EY035312 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI Milica Margeta · 2023 to 2026

$1.9M

NEI NIH HHS R01 EY035312

6 · The paper itself

Abstract

Purpose: To describe six cases of intraoperative and postoperative complications in glaucoma patients with prior or current use of netarsudil. Observation: Patients in this series all had moderate to severe glaucoma and had undergone incisional glaucoma surgery while currently or recently being exposed to netarsudil. Patients had been taking netarsudil in the affected eye for durations ranging from less than one month to six years. Most were on netarsudil within one week of the observed complication. For five patients whose surgery was done at our institution, marked conjunctival fragility was noted intraoperatively. Postoperative complications observed included tube exposures and trabeculectomy bleb leaks in the immediate postoperative period, as well as months to years later. Four of the six patients required surgical revision. Conclusion: Patients with netarsudil exposure may exhibit conjunctival fragility, which can increase the risk of intraoperative and postoperative complications from incisional glaucoma surgery.

Indexed as

ConjunctivaGlaucomaGlaucoma drainage deviceNetarsudilTrabeculectomy

Identifiers

PMID41675443

DOI10.1016/j.ajoc.2026.102533

PMCPMC12886542

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.