Evidence map›Paper›PMID 41675321›Full record

ArticleTranslational gastroenterology and hepatology2026

When should I repeat the endoscopy in my patient with compensated cirrhosis, whom I just scoped and who had no or small varices?

Joanne C Imperial, Michael P McRae, Gregory T Everson

Registry-linked trialAbstract read
In one paragraph

Article in Translational gastroenterology and hepatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00006164 (Hepatitis C Antiviral Long-term Treatment Against Cirrhosis Trial), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00006164 phase3completednot on this map

Hepatitis C Antiviral Long-term Treatment Against Cirrhosis Trial (HALT-C)

TypeinterventionalSponsorNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Ran2000 to 2009Enrolled1,050ConditionsChronic Hepatitis c, Cirrhosis, Liver, Fibrosis, Liver, Hepatic CirrhosisArmsPeginterferon alfa-2a + Ribavirin, Peginterferon alfa-2a
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Joanne C ImperialHepQuant LLC, Denver, CO, USA.
Michael P McRaeCustom DX Solutions LLC, Houston, TX, USA.ORCID https://orcid.org/0000-0002-2126-9442
Gregory T EversonHepQuant LLC, Denver, CO, USA.ORCID https://orcid.org/0000-0003-0454-3566

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endoscopic surveillance for patients with compensated advanced chronic liver disease (cACLD) is currently guided by the presence or size of esophageal varices. Current guidelines recommend repeat endoscopy every 2-3 years for patients with no varices and every 1-2 years for those with small varices, but these intervals are based largely on expert opinion rather than objective risk stratification. We evaluated the Disease Severity Index (DSI) from the oral cholate challenge test as a predictor of clinical outcomes in 195 patients from the Hepatitis C Anti-viral Long-term Treatment against Cirrhosis (HALT-C) Trial (ClinicalTrials.gov, NCT00006164) with cACLD with no or small esophageal varices. Subjects were stratified into four clinical risk categories based on DSI and platelet count: DSI ≤18.3 (low risk), DSI ≤24 with platelet count >135 nL

Indexed as

compensated advanced chronic liver disease (cACLD)Disease Severity Index (DSI)Liver functionportal hypertensionportal-systemic shunting

Identifiers

PMID41675321
PMCPMC12887276

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.