ArticleSynthetic and systems biotechnology2026
Reconstructing the hydrogenobyrinic acid synthetic toolkit by combining cell-free systems and metabolic engineering.
Article in Synthetic and systems biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Hydrogenobyrinic acid (HBA) is a pivotal intermediate in the aerobic biosynthesis of cobalamin (vitamin B12), representing a stable, metal-free corrin precursor and a useful substrate for both biological and chemical derivatization. Despite its significance, efficient HBA production remains limited by the complexity of the native cobalamin pathway, which involves more than 30 enzymatic steps and tightly regulated gene clusters. In this study, we combined
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