ArticleKidney medicine2026
Efficacy of Low-Dose Tolvaptan for Treatment of Profound Hyponatremia in Syndrome of Inappropriate Antidiuresis (SIAD): The EFFLUX-FLUID TRIAL.
Article in Kidney medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Serum Copeptin Rises After Tolvaptan for Hyponatraemia, but Does Not Predict Risk of Rapid Sodium Rise: Pre-Specified Secondary Analysis of the TVFR Trial.Clinical endocrinology · 2026Trial
- Safety and Efficacy of Tolvaptan for Acute Refractive Hyponatremia Associated with Traumatic Brain Injury.Journal of clinical medicine · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rationale & Objective: Although tolvaptan is effective for treating hyponatremia in the syndrome of inappropriate antidiuresis (SIAD), fluid restriction remains the first-line therapy because of safety concerns. This study evaluated whether low-dose tolvaptan is more effective than a combination of fluid restriction, furosemide, and sodium chloride tablets in patients with profound hyponatremia and clinical predictors of fluid restriction failure. Study Design: Single-center, open-label, randomized controlled trial. Setting & Participants: Hospitalized adults with chronic SIAD and serum sodium concentration [Na Exposures: Tolvaptan 7.5 mg/day with liberal fluid intake versus fluid restriction (800 mL/day), furosemide (20-40 mg/day), and sodium chloride tablets (3 g/day) for 28 days. Outcomes: The primary outcome was change in [Na Analytical Approach: Intention-to-treat analysis using Results: Mean baseline [Na Limitations: Small sample size and single-center design. Conclusions: Low-dose tolvaptan effectively and rapidly increases [Na
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