Evidence map›Paper›PMID 41675034›Full record

ArticlePhysics and imaging in radiation oncology2026

Standardising image registration and dose mapping for thoracic reirradiation: A national multi-centre benchmarking study.

Hella Sand, Dennis Arp, Maria F Jensen, Marianne M Knap, Christina Larsen, Mikkel D Lund, Morten Nielsen, Wiviann Ottosson, Ane Appelt, Lone Hoffmann

Abstract read
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In one paragraph

Article in Physics and imaging in radiation oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hella SandDepartment of Oncology, Aalborg University Hospital, Aalborg, Denmark.
Dennis ArpDepartment of Oncology, Aalborg University Hospital, Aalborg, Denmark.
Maria F JensenDanish Centre for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark.
Marianne M KnapDepartment of Oncology, Aarhus University Hospital, Aarhus, Denmark.
Christina LarsenDepartment of Oncology, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark.
Mikkel D LundDepartment of Oncology, Vejle Hospital, University Hospital of Southern Denmark, Vejle, Denmark.
Morten NielsenDepartment of Oncology, Odense University Hospital, Odense, Denmark.
Wiviann OttossonDepartment of Oncology, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark.
Ane AppeltLeeds Institute of Medical Research, University of Leeds, Leeds, United Kingdom.
Lone HoffmannDepartment of Oncology, Aarhus University Hospital, Aarhus, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and purpose: Safe delivery of high-dose reirradiation depends on robust evaluation of previously delivered dose on current patient anatomy. This study aims to assess the variability of 1) rigid (RIR) and deformable (DIR) image registration, and 2) dose-mapping based on RIR or DIR, as part of the pre-trial quality assurance for CURE Lung, a Scandinavian thoracic reirradiation trial. Materials and methods: Seven lung cancer cases, treated with curatively intended reirradiation near a previously irradiated region, were distributed to six Danish centres. Organs-at-risk (OARs) were delineated on CT images of previous (CT Results: DIR significantly reduced the geometrical variations for all OARs, with mean surface distances <4.4 mm. Near-maximum EQD2-doses overall had less variability with DIR compared to RIR. No significant differences were found for the full DVH bands. Conclusion: DIR provides significantly better consistency in transfer of OAR from CT

Indexed as

Deformable image registration (DIR)Dose mappingDVH analysisImage registration variabilityLung cancerMulticentre studyQuality assuranceRadiotherapyRigid image registration (RIR)Thoracic reirradiation

Identifiers

PMID41675034
PMCPMC12886061

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.