Evidence map›Paper›PMID 41674994›Full record

ArticleTranslational cancer research2026

GNAL-driven calcium signaling reshapes the spatiotemporal immune landscape in ER

Jing Zeng, Dongchen Tian, Jiahui Zhang, Guixin Wang, Yingxi Li, Yue Yu, Yao Tian, Jinxian He, Weiyu Shen, Zhaohui Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jing Zeng *Department of Thoracic Surgery, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, China.
Dongchen Tian *The First Department of Breast Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China.
Jiahui Zhang *The First Department of Breast Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China.
Guixin WangThe First Department of Breast Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China.
Yingxi LiHealth Science Center, Ningbo University, Ningbo, China.
Yue YuThe First Department of Breast Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China.
Yao TianDepartment of Thoracic Surgery, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, China.
Jinxian HeDepartment of Thoracic Surgery, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, China.
Weiyu ShenDepartment of Thoracic Surgery, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, China.
Zhaohui ChenThe First Department of Breast Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Endocrine-resistant estrogen receptor-positive (ER Methods: To elucidate the regulatory role of GNAL, we integrated summary-based Mendelian randomization (SMR), single-cell RNA sequencing, and spatial transcriptomics. Causal inference, cell-type mapping, and intercellular communication networks were analyzed, and a multi-omics prognostic model was constructed and validated across The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) cohorts. Results: SMR analysis identified GNAL as a causal gene for ER Conclusions: GNAL regulates the spatiotemporal immune remodeling of ER

Indexed as

calcium signaling pathwaysGNALprognostic modelspatial transcriptomicstumor microenvironment (TME)

Identifiers

PMID41674994
PMCPMC12885893

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.