Evidence map›Paper›PMID 41674950›Full record

ArticleTranslational cancer research2026

Hsa_circ_0001756, a novel biomarker, promotes breast cancer progression via miR-584-5p/TRAF6 signaling axis.

Jun-Ying Wu, Xi-Xi Wu, Li-Yan Shi, Ling-Xia Wang, Ying Cao, Xue-Jun Shao, Bo Wang, Huan Yang

Abstract read
In one paragraph

Article in Translational cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jun-Ying Wu *Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Xi-Xi Wu *Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Li-Yan ShiDepartment of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Ling-Xia WangDepartment of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Ying CaoDepartment of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Xue-Jun ShaoDepartment of Clinical Laboratory, The Children's Hospital of Soochow University, Suzhou, China.
Bo WangDepartment of Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Huan YangDepartment of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Circular RNAs (circRNAs) appear to exert critical functions in breast cancer (BC). The objective of this study is to explore the usefulness of circRNAs as potential diagnostic and prognostic biomarkers of BC. Methods: The Gene Expression Omnibus (GEO) database was referenced to identify differentially expressed circRNAs in BC. Quantitative real-time polymerase chain reaction (qPCR) was used to detect the expression levels of hsa_circ_0001756 in both BC tissue samples and BC-derived cell lines. The functions of hsa_circ_0001756 were investigated both Results: Hsa_circ_0001756 expression was upregulated in BC tissues and substantially correlated with tumor size and tumor-node-metastasis (TNM) stage. Knockdown (KD) of hsa_circ_0001756 markedly inhibited the malignant potential of BC both Conclusions: Our findings indicated that hsa_circ_0001756 could promote BC malignant progression through the miR-584-5p/TRAF6 signaling axis. Especially, hsa_circ_0001756 in serum holds promise as a biomarker for BC screening and diagnosis.

Indexed as

biomarkerbreast cancer (BC)Hsa_circ_0001756miR-584-5pTRAF6

Identifiers

PMID41674950
PMCPMC12885921

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.