ArticleTranslational cancer research2026
Therapeutic efficacy evaluation of the injection mucosa knife in endoscopic submucosal dissection for rectal neuroendocrine tumors.
Article in Translational cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Endoscopic submucosal dissection (ESD) is preferred for rectal neuroendocrine tumors (NETs), yet technical refinements are needed. This study aims to analyze the therapeutic efficacy of the injection mucosa knife (IMK) in ESD for rectal NETs. Methods: This retrospective study analyzed data from patients with rectal NETs undergoing ESD at three tertiary hospitals from January 2021 to December 2024, with 86 cases in the IMK group and 74 cases in the traditional Dual knife (DK) group. Primary endpoints comprised operative time, R0 resection rate, and complication incidence. Logistic regression was used to identify risk factors for positive vertical margins. Results: The preoperative demographic and clinical features of both groups were comparable (P>0.05). Notably, 72.5% of patients had tumors <5.0 mm, and 88.8% exhibited submucosal invasion. The IMK group showed shorter operative time (7.25 Conclusions: In the ESD treatment of rectal NETs, the IMK can shorten operative time and reduce muscular layer injury compared to the traditional DK. Moreover, it achieves a low incidence of postoperative complications, making it worthy of clinical promotion and application.
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