Evidence map›Paper›PMID 41674910›Full record

ArticleOsteoarthritis and cartilage open2026

A small lipidated peptide targeting Na

Raider Rodriguez, Arin Bhattacharjee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoarthritis and cartilage open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Raider RodriguezPharmacology and Toxicology, University at Buffalo - The State University of New York, Buffalo, NY 14203, USA.
Arin BhattacharjeePharmacology and Toxicology, University at Buffalo - The State University of New York, Buffalo, NY 14203, USA.

Funding

Disrupting Ion Channel Scaffolding to Treat Neuropathic PainRF1NS113991 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI BHATTACHARJEE, ARINDAM · 2019 to 2019
$1.9M
The Role of the Nociceptor Endocytosis in Inflammatory PainR01NS128543 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Arindam Bhattacharjee · 2022 to 2026
$1.9M
NINDS NIH HHS R01 NS128543NINDS NIH HHS RF1 NS113991
6 · The paper itself

Abstract

Objective: In clinical practice, intra-articular therapies are commonly used for the management of osteoarthritis (OA) pain. However, these current treatments for OA-related pain are recognized for compromising joint integrity over time. Previously, we demonstrated that disrupting the interaction between Na Methods: In vivo shRNA plasmid transfection was used to knock down Magi-1 in mouse DRG neurons to assess its effects on MIA-induced osteoarthritis (OA) pain behavior. Subsequently, a lipidated Na Results: Magi-1 knockdown effectively reduced established OA pain in mice. An intra-articular injection of the PY(A) peptide inhibited pain for multiple weeks in rats. MicroCT imaging showed minimal changes in subchondral bone remodeling in the PY(A) peptide group compared to the scrambled peptide group. Conclusions: The PY(A) peptide targeting the Na

Indexed as

AnalgesiaBone remodelingIntra-articular injectionPeptideSodium channels

Identifiers

PMID41674910
PMCPMC12886057

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.