ArticleResearch square2026
Cholinergic substrates of gait and postural impairments in Progressive Supranuclear Palsy.
Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
Purpose: Progressive Supranuclear Palsy (PSP) is an atypical parkinsonian syndrome characterized by significant postural instability and gait difficulties (PIGD). While brain cholinergic deficits are documented in PSP, their role in the pathophysiology of PIGD is an area of active research. This cross-sectional study aimed to elucidate relationships between regional cholinergic denervation, assessed by [ Methods: Nineteen subjects characterized clinically as PSP (twelve males, seven females; mean age of 69.47 ± 6.46 years [range 55-79]). Based on the Movement Disorders Society-PSP diagnostic criteria, sixteen patients had probable PSP (eleven males; five females) and three had suggestive PSP (one male; two females). Clinical assessments showed significant motor impairments, a mean MDS-UPDRS Part III "off state" score of 42.36 ± 13.52 and a mean modified Hoehn and Yahr stage of 3.36 ± 1.22. Results: Statistical parametric mapping (SPM) based voxel-wise analysis of [ Conclusions: These findings highlight the potential roles of cholinergic systems degenerations in mediating PIGD in PSP. This suggests that cholinergic systems degeneration plays a substantial role in the pathophysiology of PIGD in PSP, offering a potential avenue for targeted therapeutic interventions to improve mobility and quality of life for these patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.