ArticleResearch square2026
Cerebrospinal fluid proteomic signatures reveal
Zhiyuan Ning, Jeff Y L Lam, Zonghua Li, Yuka A Martens, Sydney V Doss, Senne B Lageman, Maria Vassilaki, Ronald C Petersen, Chia-Chen Liu, Michael G Heckman and 3 more
Abstract readPreprint
In one paragraphArticle in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
13 authors.
Zhiyuan NingDivision of Life Science and State Key Laboratory of Nervous System Disorders, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
Jeff Y L LamDivision of Life Science and State Key Laboratory of Nervous System Disorders, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.ORCID 0000-0001-7408-2342 Zonghua LiDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, United States.
Yuka A MartensDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, United States.
Senne B LagemanAlzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, 1081HZ Amsterdam, North-Holland, The Netherlands.
Maria VassilakiDepartment of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, United States.
Ronald C PetersenDepartments of Neurology, Mayo Clinic, Rochester, MN, United States.
Chia-Chen LiuDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, United States.
Michael G HeckmanDepartment of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, United States.
Betty M TijmsAlzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, 1081HZ Amsterdam, North-Holland, The Netherlands.ORCID 0000-0002-2612-1797 Guojun BuDivision of Life Science and State Key Laboratory of Nervous System Disorders, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.ORCID 0000-0003-3491-1016 Funding
Project 4 (Genetic modifiers for APOE-associated Alzheimer's disease pathogenesis)U19AG069701 · NIA · MAYO CLINIC JACKSONVILLE · PI Takahisa Kanekiyo · 2021 to 2026
$42.0MImpact of ApoE2 on aging-related conditionsRF1AG057181 · NIA · MAYO CLINIC JACKSONVILLE · PI KANEKIYO, TAKAHISA · 2018 to 2018
$3.7MNIA NIH HHS RF1 AG057181NIA NIH HHS U19 AG069701
6 · The paper itselfAbstract
Cerebrospinal fluid (CSF) proteomics offers insights into molecular changes in aging and Alzheimer's disease (AD). Key AD biomarkers, in particular amyloid-β (Aβ) and tau, in CSF are strongly associated with
Indexed as
Alzheimer’s diseaseAPOECSF proteomicslipid metabolismneuroinflammation
Identifiers
PMID41674829
PMCPMC12889836
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