Evidence map›Paper›PMID 41674827›Full record

ArticleResearch square2026

Non-equilibrium active noise enhances generative memory in diffusion models.

Agnish Kumar Behera, Alexandra Lamtyugina, Aditya Nandy, Daiki Goto, Carlos Floyd, Suriyanarayanan Vaikuntanathan

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Agnish Kumar BeheraDepartment of Chemistry, University of Chicago, Chicago, IL, 60637.
Alexandra LamtyuginaDepartment of Chemistry, University of Chicago, Chicago, IL, 60637.
Aditya NandyDepartment of Chemistry, University of Chicago, Chicago, IL, 60637.ORCID 0000-0001-7137-5449
Daiki GotoDepartment of Physics, University of Chicago, Chicago, IL, 60637.
Carlos FloydDepartment of Chemistry, University of Chicago, Chicago, IL, 60637.ORCID 0000-0002-6270-7250
Suriyanarayanan VaikuntanathanDepartment of Chemistry, University of Chicago, Chicago, IL, 60637.

Funding

Elucidating biophysical mechanisms for force sensing and control using non-equilibrium statistical mechanics and AIR35GM147400 · NIGMS · UNIVERSITY OF CHICAGO · PI Suriyanarayanan Vaikuntanathan · 2022 to 2026
$1.9M
NIGMS NIH HHS R35 GM147400
6 · The paper itself

Abstract

Generative diffusion models have emerged as powerful tools for sampling high-dimensional distributions, yet they typically rely on white gaussian noise and noise schedules to destroy and reconstruct information. Here, we demonstrate that driving the generative process out of equilibrium using active, temporally correlated noise sources fundamentally alters the information thermodynamics of the system. We show that coupling the data to an active non-Markovian bath creates a 'memory effect' where high-level semantic information (such as class identity or molecular metastability) is stored in the temporal correlations of auxiliary degrees of freedom. Using Fisher information analysis, we prove that this active mechanism significantly retards the rate of information decay compared to passive Brownian motion. Crucially, this memory effect facilitates an earlier and more robust symmetry breaking (speciation) during the reverse generative process, allowing the system to resolve multi-scale structures, reminiscent of metastable states in molecular configurations that are washed out in the typical noising processes. Our results suggest that non-equilibrium protocols, inspired by active matter physics, offer a thermodynamically distinct and potentially advantageous pathway for recovering high-dimensional energy landscapes using generative diffusion.

Identifiers

PMID41674827
PMCPMC12889839

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.